Cardinals quarterback Kyler Murray was carted off the field after suffering a non-contact knee injury during Arizona’s opening drive and did not return.

New England finished the game on a 20-0 run that included a go-ahead fumble recovery TD from linebacker Raekwon McMillan with 5:32 left in the third quarter.

Murray went down without being touched and stayed down, an ugly precursor to what is usually bad news. The right knee injury knocked him from the game, and then coach Kliff Kingsbury – while not getting specific – acknowledged the obvious.

"It doesn't look good," Kingsbury said, after the Cardinals lost to the Patriots, 27-13, in a result that felt like only a secondary headline. "We'll know more in the morning."

 Colt McCoy was sacked six times and went 27-of-40 for 246 passing yards and an interception in place of Murray.

Patriots running back Rhamondre Stevenson (ankle) and wide receiver DeVante Parker (head) were also ruled out of the game with injuries.

The Patriots kicked a field goal on the final play of the half, tied it to start the second half, and then turned a DeAndre Hopkins fumble into a 23-yard touchdown return by linebacker Raekwon McMillan to take a lead they never relinquished.

The Cardinals had gotten out to a good start, with a nine-yard pass from Murray to running back James Conner, and then a six-yard Conner run. But then Murray dropped back, had to scramble, and everything changed.